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Efficacy of the AZD1222 (ChAdOx1 nCoV-19) COVID-19 Vaccine Against SARS-CoV-2 Variants of Concern (preprint)

Anthonet L. Koen; Alane Izu; Vicky Baillie; Gaurav Kwatra; Clare L. Cutland; Lee Fairlie; Sherman D. Padayachee; Keertan Dheda; Shaun L. Barnabas; Qasim Ebrahim Bhorat; Carmen Briner; Katija Ahmed; Sutika Bhikha; Jinal N. Bhiman; Jeanine du Plessis; Aliasgar Esmail; Elizea Horne; Shi-Hsia Hwa; Aylin Oomen-Jose; Teresa Lambe; Matt Laubscher; Mookho Malahleha; Gabriella Benade; Shakeel McKenzie; Suzette Oelofse; Faeezah Patel; Sureshnee Pillay; Sarah Rhead; Hylton Rodel; Carol Taoushanis; Houriiyah Tegally; Asha Thombrayil; Tonya Villafana; Sarah Gilbert; Andrew J. Pollard; Shabir Madhi.

medrxiv; 2022.

Preprint in English | medRxiv | ID: ppzbmed-10.1101.2022.07.18.22277743

ABSTRACT

In this South African phase 1/2b study, we demonstrated vaccine efficacy (VE) of two doses of AZD1222 for asymptomatic and symptomatic SARS-CoV-2 infection: 90.6% against wild-type and 77.1% against the Delta variant [≥]9 months after vaccination. VE against infection with the Beta variant, which preceded circulation of Delta, was 6.7%. Clinical trial identifierCT.gov NCT04444674

Subject(s)

COVID-19

Clinical Characteristics and Histopathology of COVID-19 Related Deaths in South African Adults (preprint)

Marta C. Nunes; Martin J. Hale; Sana Mahtab; Fikile Mabena; Noluthando Dludlu; Vicky L. Baillie; Nana Thwala; Toyah Els; Jeanine Du Plessis; Marius Laubscher; Shakeel Mc Kenzie; Sihle Mtshali; Colin Menezes; Natali Serafin; Sarah van Blydenstein; Merika Tsitsi; Brian Dulisse; Shabir A. Madhi.

ssrn; 2021.

Preprint in English | PREPRINT-SSRN | ID: ppzbmed-10.2139.ssrn.3883275

Subject(s)

COVID-19

Safety and efficacy of the ChAdOx1 nCoV-19 (AZD1222) Covid-19 vaccine against the B.1.351 variant in South Africa (preprint)

Shabir Ahmed Madhi; Vicky Lynne Baillie; Clare Louise Cutland; Merryn Voysey; Anthonet L Koen; Lee Fairlie; Sherman D Padayachee; Keertan Dheda; Shaun L Barnabas; Qasim Ebrahim Bhorat; Carmen Briner; Gaurav Kwatra; Khatija Ahmed; Parvinder Aley; Sutika Bhikha; Jinal N Bhiman; As'ad Ebrahim Bhorat; Jeanine du plessis; Aliasgar Esmail; Marisa Groenewald; Elizea Horne; Shi-Hsia Hwa; Aylin Jose; Teresa Lambe; Matt Laubscher; Mookho Malahleha; Masebole Masenya; Mduduzi Masilela; Shakeel McKenzie; Kgaogelo Molapo; Andrew Moultrie; Suzette Oelofse; Faeezah Patel; Sureshnee Pillay; Sarah Rhead; Hylton Rodel; Lindie Rossouw; Carol Taoushanis; Houryiah Tegally; Asha Thombrayil; Samuel van Eck; Constantinos Wibmer; Nicholas M Durham; Elizabeth J Kelly; Tonya Villafana; Sarah Gilbert; Andrew J Pollard; Tulio de Oliveira; Penny L Moore; Alex Sigal; Alane Izu; - Network for Genomic Surveillance in South Africa (NGS-SA); - Wits VIDA COVID vaccine trial group.

medrxiv; 2021.

Preprint in English | medRxiv | ID: ppzbmed-10.1101.2021.02.10.21251247

Subject(s)

COVID-19

ABSTRACT

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